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Journal of Science and Engineering Papers

Doi: https://doi.org/10.62275/josep.24.1000001

ISSN: 3006-3191 (Online)

ISSN: 3079-8175 (Print)

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Design and Performance of a Chemically Crosslinked CMC/PVP Hydrogel for Drug Release

HomeAll PostsLatestDesign and Performance of a Chemically...
Volume: 03
Issue: 01
Views: 36
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Original Research Article
Pharmaceutical Science
Design and Performance of a Chemically Crosslinked CMC/PVP Hydrogel for Drug Release
Most. Arifa Sultana, Md. Shameem Ahsan, Ajit Mondal, Anoy Chowdhury, Md. Abdul Hassib, Afsar Alom, Antor Kumer Mondol, and Md. Tamzid Hossain Molla*
Department of Applied Chemistry and Chemical Engineering, University of Rajshahi, Rajshahi-6205, Bangladesh
Year: 2026
Page: 145-152
Doi: 10.62275/josep.26.1000023

This work is licensed under CC BY-SA 4.0

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Abstract

Rice husk is an abundant natural resource that contains about 33% cellulose. Here we focused on the extraction and develop of carboxymethyl cellulose (CMC) from rice husks and its utilization in developing CMC-polyvinylpyrrolidone (PVP) blended hydrogel (HGEL) membranes with varying CMC:PVP ratios (80:20, 60:40, and 50:50 w/w). The controlled release of pharmaceuticals and targeted drug administration depend on pH-responsive drug delivery systems. We synthesized an innovative pH-sensitive, biodegradable, and antibacterial hydrogels through blending and solution casting method, using glutaraldehyde as a crosslinking agent. Structural and physicochemical characterization confirmed successful hydrogel formation: FTIR validated crosslinked network development, TGA demonstrated enhanced thermal stability, and SEM revealed uniform and interconnected morphologies. Swelling studies showed that swelling capacity could be precisely tuned by altering the CMC/PVP composition, with higher pH conditions markedly increasing swelling, confirming the pH-responsive behavior of the hydrogels. The drug (salicylic acid) release profiles from gel membrane were conducted into two separate release media (pH 1.4, and pH 7.4), with samples evaluated spectrophotometric analysis at 294 nm wavelength using a UV-Vis spectrophotometer, showed a consistent and controlled release profile. Biodegradability tests in soil revealed that the hydrogel sample degraded gradually up to 72.65% within 15 days. Moreover, upon testing on  bacteria Staphylococcus aureus (G+) & Escherichia coli (G-) bacterium, the sample (50:50) gave 11 mm of inhibition zone diameter which confirmed that the synthesized hydrogel can be used for wound dressing and other biomedical applications. Altogether hydrogels underlined as a prospective category of eco-friendly and tunable biomaterials for future healthcare innovations.

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How to Cite

Most. Arifa Sultana, Md. Shameem Ahsan, Ajit Mondal, Anoy Chowdhury, Md. Abdul Hassib, Afsar Alom, Antor Kumer Mondol, and Md. Tamzid Hossain Molla*
I.H. 2024. Design and Performance of a Chemically Crosslinked CMC/PVP Hydrogel for Drug Release. Journal of Science and Engineering Papers . 
January 21, 2026.
  Doi: 10.62275/josep.26.1000023.
Most. Arifa Sultana, Md. Shameem Ahsan, Ajit Mondal, Anoy Chowdhury, Md. Abdul Hassib, Afsar Alom, Antor Kumer Mondol, and Md. Tamzid Hossain Molla*
Design and Performance of a Chemically Crosslinked CMC/PVP Hydrogel for Drug Release.
  journal 2026, 21.
Most. Arifa Sultana, Md. Shameem Ahsan, Ajit Mondal, Anoy Chowdhury, Md. Abdul Hassib, Afsar Alom, Antor Kumer Mondol, and Md. Tamzid Hossain Molla*
I.H. 2024. Design and Performance of a Chemically Crosslinked CMC/PVP Hydrogel for Drug Release. .Journal of Science and Engineering Papers . 
21 (1).
  https://doi.org/10.62275/josep.26.1000023.
Most. Arifa Sultana, Md. Shameem Ahsan, Ajit Mondal, Anoy Chowdhury, Md. Abdul Hassib, Afsar Alom, Antor Kumer Mondol, and Md. Tamzid Hossain Molla*
I.H. Design and Performance of a Chemically Crosslinked CMC/PVP Hydrogel for Drug Release. Journal of Science and Engineering Papers . 
2026.
Most. Arifa Sultana, Md. Shameem Ahsan, Ajit Mondal, Anoy Chowdhury, Md. Abdul Hassib, Afsar Alom, Antor Kumer Mondol, and Md. Tamzid Hossain Molla*
2024." Design and Performance of a Chemically Crosslinked CMC/PVP Hydrogel for Drug Release." Journal of Science and Engineering Papers . 
21 (1).
  https://doi.org/10.62275/josep.26.1000023.
Most. Arifa Sultana, Md. Shameem Ahsan, Ajit Mondal, Anoy Chowdhury, Md. Abdul Hassib, Afsar Alom, Antor Kumer Mondol, and Md. Tamzid Hossain Molla*
I.H. 2024. " Design and Performance of a Chemically Crosslinked CMC/PVP Hydrogel for Drug Release." Journal of Science and Engineering Papers . 
21 (1).
  https://doi.org/10.62275/josep.26.1000023.
Most. Arifa Sultana, Md. Shameem Ahsan, Ajit Mondal, Anoy Chowdhury, Md. Abdul Hassib, Afsar Alom, Antor Kumer Mondol, and Md. Tamzid Hossain Molla*
, "Design and Performance of a Chemically Crosslinked CMC/PVP Hydrogel for Drug Release". .Journal of Science and Engineering Papers . 
  journal Jan, 2026.
Most. Arifa Sultana, Md. Shameem Ahsan, Ajit Mondal, Anoy Chowdhury, Md. Abdul Hassib, Afsar Alom, Antor Kumer Mondol, and Md. Tamzid Hossain Molla*
"Design and Performance of a Chemically Crosslinked CMC/PVP Hydrogel for Drug Release." Journal of Science and Engineering Papers . 
Jan, 2026.
  https://doi.org/10.62275/josep.26.1000023.
Most. Arifa Sultana, Md. Shameem Ahsan, Ajit Mondal, Anoy Chowdhury, Md. Abdul Hassib, Afsar Alom, Antor Kumer Mondol, and Md. Tamzid Hossain Molla*
"Design and Performance of a Chemically Crosslinked CMC/PVP Hydrogel for Drug Release." Journal of Science and Engineering Papers . 
(Jan 21, 2026).
  https://doi.org/10.62275/josep.26.1000023.
Most. Arifa Sultana, Md. Shameem Ahsan, Ajit Mondal, Anoy Chowdhury, Md. Abdul Hassib, Afsar Alom, Antor Kumer Mondol, and Md. Tamzid Hossain Molla*
Design and Performance of a Chemically Crosslinked CMC/PVP Hydrogel for Drug Release. Journal of Science and Engineering Papers . 
  journal [ Internet ] 21 Jan, 2026.
  [ Cited 21 Jan, 2026 ]
21 (1).
  https://doi.org/10.62275/josep.26.1000023.

Keywords

rice husk, carboxymethyl cellulose, pH-responsive hydrogel, biodegradable, antimicrobial, drug delivery system

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